Supplementary Figure 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759771

Key Points

Tumor suppressor genes show distinct distance distribution patterns in relation to segmental duplications.
Significant differences in nearest segmental duplications were found for oncogenes and non-cancer genes.
The analysis utilized boxplots to visualize gene distances, with notable results occurring at p < 0.05.
Understanding these distances may aid in assessing the risk of somatic deletions and structural variations in cancers.

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Implication

Boxplot reveals significant differences in distance distribution of TSGs and oncogenes to segmental duplications, highlighting their vulnerability to structural variations.

Abstract

Boxplot showing the distance distribution of non-cancer genes, oncogenes, and TSGs to their nearest SDs, with individual genes represented as dots and significant differences marked (p < 0.05).

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02d1 https://doi.org/10.1158/0008-5472.29759771

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Supplementary Figure 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 3 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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