Supplementary Figure 14 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

A positive correlation exists between SD repeat number and somatic deletions in tumor suppressor genes.
Somatic non-CNA structural variation frequency is influenced by the presence of segmental duplications in TSGs.
This analysis covers findings from 37 different tumor types in the TCGA database.
Understanding these relationships may provide insights into cancer genetics and tumor behavior.

Answers are grounded in this paper and cite their sources.

Positive correlation found between SD repeat number and somatic deletions in tumor suppressor genes, highlighting structural variation implications.

Positive correlation between SD repeat number and somatic non-CNA SV frequency in TSGs with SDs across 37 TCGA cancers.

No takes yet. Share an insight, caveat, or question.

Huang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Share