Supplementary Figure 16 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759804

Key Points

Main finding reveals a positive correlation between gene size and mutation frequency in tumor suppressor genes with segmental duplications.
Key evidence shows that larger tumor suppressor genes tend to experience more nonsynonymous and frameshift mutations across 33 types of cancers.
Approach involved analyzing 33 cancers to assess the relationship between gene size and mutation frequency in tumor suppressor genes.
Significance lies in understanding how structural variations affect tumor suppressor genes, potentially guiding cancer research and therapies.

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Implication

Positive correlation exists between gene size and mutation frequency in tumor suppressor genes, indicating structural variations may play a role in cancer.

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Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d030c https://doi.org/10.1158/0008-5472.29759804

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Supplementary Figure 16 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 16 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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