Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759825

Key Points

A positive correlation exists between segmental duplication repeat number and deletion frequency in tumor suppressor genes.
The analysis covered 33 cancer types documented by The Cancer Genome Atlas (TCGA).
Homozygous deletions are more frequent in tumor suppressor genes with higher segmental duplication counts.
These findings suggest structural variations pose significant risks in cancer development and progression.

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Implication

Analysis reveals a positive correlation between segmental duplication frequency and homozygous deletion rates in tumor suppressor genes across 33 cancers, indicating structural vulnerabilities.

Abstract

Positive correlation between SD repeat number and homozygous deletion frequency in SD-containing TSGs across 33 TCGA cancers.

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Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02b8 https://doi.org/10.1158/0008-5472.29759825

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Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 11 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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