Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759819

Key Points

Main finding reveals that tumor suppressor genes with segmental duplications have higher rates of somatic deletions.
Evidence shows a significant increase in structural variations, including translocations and inversions, in these genes.
The research uses comparative analysis across various cancers to assess the frequency of somatic variations.
This work underscores the role of segmental duplications in genomic instability related to cancer development.

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Implication

Analysis shows higher frequency of structural variations in tumor suppressor genes with segmental duplications, indicating an increased risk across cancers.

Abstract

Higher somatic non-CNA SV frequency (translocations/inversions) in TSGs with SDs versus TSGs without SDs across cancers.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02d4 https://doi.org/10.1158/0008-5472.29759819

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Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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