Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka–Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.30235107

Key Points

Increased frequency of somatic deletions was observed in tumor suppressor genes with segmental duplications.
The study highlights the significant difference in structural variations between oncogenes with and without segmental duplications.
Using a comparative analysis, both oncogenes and tumor suppressor genes were evaluated based on their somatic variation patterns.
Potential implications for cancer research point to a need to focus on structural variations linked to segmental duplications.

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Implication

Analysis shows increased somatic deletions in tumor suppressor genes with segmental duplications, indicating a potential mechanism for structural variations.

Abstract

Somatic non-CNA SV frequency comparison for oncogenes with/without SDs.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb1625 https://doi.org/10.1158/0008-5472.30235107

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Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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