Supplementary Figure 15 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Tumor suppressor genes with segmental duplications show an increased frequency of somatic deletions.
Analysis indicates that oncogenes without segmental duplications have lower rates of structural variations.
Non-core mutations appear more frequently in segments with duplications, affecting tumor progression.
Understanding these variations can help in assessing cancer risks and developing targeted therapies.

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Comparative analysis reveals somatic deletion frequency in oncogenes with segmental duplications, suggesting higher risk.

Somatic non-CNA SV frequency comparison for oncogenes with/without SDs.

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Huang et al. (2025) studied this question.

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