Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka–Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.30235113

Key Points

Increased somatic structural variations occur more frequently in tumor suppressor genes containing segmental duplications.
The study reports that tumor suppressor genes with segmental duplications have a higher rate of structural variations compared to those without.
Segmental duplications in tumor suppressor genes may lead to significant implications in cancer development and genetics.
Investigation highlights the relationship between segmental duplications and structural variations in oncogenesis.

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Implication

Analysis reveals higher somatic structural variation in tumor suppressor genes with segmental duplications, suggesting potential implications for cancer development.

Abstract

Higher somatic non-CNA SV frequency (translocations/inversions) in TSGs with SDs versus TSGs without SDs across cancers.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e358a7d58c25ebb1647 https://doi.org/10.1158/0008-5472.30235113

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Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 13 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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