Supplementary Figure 17 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759798

Key Points

MAIN FINDING: Tumor suppressor genes with segmental duplications show increased susceptibility to structural variations.
KEY EVIDENCE: Data indicate a higher missense mutation frequency in oncogenes containing segmental duplications.
APPROACH: The study compares mutation rates between oncogenes with and without segmental duplications.
SIGNIFICANCE: Understanding these mutations may lead to better insights into cancer genetics and treatment strategies.

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Implication

Analysis reveals higher missense mutation rates in oncogenes with segmental duplications, suggesting structural variations influence genetic instability.

Abstract

Higher missense mutation frequency in with SDs versus without SDs oncogenes.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02fe https://doi.org/10.1158/0008-5472.29759798

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Supplementary Figure 17 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 17 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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