Supplementary Figure 18 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759795

Key Points

MAIN FINDING: Tumor suppressor genes with segmental duplications are more susceptible to somatic deletions and structural variations.
KEY EVIDENCE: Analysis shows a positive correlation between gene size and missense mutation frequency in oncogenes.
APPROACH: The study examined data from 33 TCGA cancers to identify patterns in gene behavior and mutations.
SIGNIFICANCE: Understanding these correlations may help clarify the mechanisms behind cancer progression and gene stability.

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Implication

Positive correlation between mutation frequency and gene size in oncogenes with segmental duplications across 33 cancers, indicating structural variation risks.

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02e9 https://doi.org/10.1158/0008-5472.29759795

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Supplementary Figure 18 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 18 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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