Supplementary Figure 21 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

No significant difference in structural variations between genes with segmental duplications and those without.
Ionizing radiation-induced somatic deletions do not vary across normal human cell colonies with different gene structures.
This research indicates that segmental duplications may not impact SV occurrence in tumor suppressor genes.
Findings may help refine understanding of genetic vulnerabilities affecting tumor suppressor genes.

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Findings show no significant difference in somatic deletions in tumor suppressor genes with segmental duplications, suggesting similar SV outcomes.

No significant difference in ionizing radiation-induced SV between with SDs and without SDs genes across normal human cell colonies.

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Huang et al. (2025) studied this question.

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