Supplementary Figure 12 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Ziheng Huang; Lin Zhang; Huarong Chen; Xiaodong Liu; Likai Tan; Dan Huang; Yingzhi Liu; Yushan Wang; Xinyi Zhang; Alfred S.L. Cheng; Maggie Haitian Wang; Wei Kang; Ka‐Fai To; Jun Yu; Ho Ko; Le Yu; Sunny H. Wong; Tony Gin; Matthew T.V. Chan; Xiansong Wang; William Ka Kei Wu

doi:10.1158/0008-5472.29759822

Key Points

Tumor suppressor genes with segmental duplications show a higher susceptibility to somatic deletions and structural variations.
Meta-analysis indicates that oncogene amplification revealed no significant differences based on the presence of segmental duplications.
Methodology involved analyzing GISTIC scores to assess oncogene amplification levels in various subjects.
Findings highlight the need to further explore the relationship between structural variations and tumorigenesis in cancer research.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Meta-analysis reveals no significant difference in oncogene amplification between those with segmental duplications and those without, suggesting structural variations impact tumor genetics.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02ba https://doi.org/10.1158/0008-5472.29759822

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure 12 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 12 from Tumor Suppressor Genes with Segmental Duplications Are Prone to Somatic Deletions and Structural Variations

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading