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August 4, 2025

Figure S3 from m⁶A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb

Tingting Xia Menglei Chen Meiyu Zhou Weiping Wan Yifan Shan Weijia Xie Na Wu Chengying Li Zhiquan Yuan Tongjian Cai Zubin Yu Ying Xiang Li Bai Yafei Li

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Key Points

MAIN FINDING: SFTA1P acts as a tumor suppressor in non-small cell lung cancer by regulating key signaling pathways.
KEY EVIDENCE: Correlations between SFTA1P and downstream target genes of the TGF-β signaling pathway support this role.
APPROACH: The study evaluates gene expression relationships and the impact on cell signaling in lung cancer.
SIGNIFICANCE: Understanding SFTA1P's role may lead to new strategies for targeting tumor suppressor mechanisms in cancer therapy.

Implication

Analysis shows SFTA1P regulates tgfbr2 and p-tefb in non-small cell lung cancer, suggesting its role as a tumor suppressor.

Abstract

The gene expression correlations between SFTA1P and downstream target genes of TGF-β signaling pathway.

Discussion

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Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0999 https://doi.org/10.1158/1541-7786.29819544

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S4 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
2Figure S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
3Figure S2 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
4Figure S6 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
5Figure S5 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025

Table S1 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
Figure S8 from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025
Data from m<sup>6</sup>A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb2025