Figure S5 from m⁶A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb

Tingting Xia; Menglei Chen; Meiyu Zhou; Weiping Wan; Yifan Shan; Weijia Xie; Na Wu; Chengying Li; Zhiquan Yuan; Tongjian Cai; Zubin Yu; Ying Xiang; Li Bai; Yafei Li

doi:10.1158/1541-7786.29819538

August 4, 2025

Figure S5 from m⁶A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb

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Key Points

MAIN FINDING: SFTA1P acts as a tumor suppressor in non-small cell lung cancer through its influence on TGFBR2.
KEY EVIDENCE: Protein expression of E-cadherin and Vimentin was analyzed in H1299 cells treated with specific siRNA.
APPROACH: The study used Western blotting to evaluate protein levels following siRNA and BAY-1143572 treatments.
SIGNIFICANCE: Understanding SFTA1P's role might offer new insights into therapeutic strategies for lung cancer.

Implication

Research demonstrates SFTA1P's tumor suppressor role in non-small cell lung cancer, suggesting its impact on TGFBR2 and P-TEFb regulation.

Abstract

The protein expression of E-cadherin and Vimentin were evaluated by WB in H1299 cells after treated with siRNA targeting SFTA1P and BAY-1143572 (1μM).

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Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0992 https://doi.org/10.1158/1541-7786.29819538

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Figure S5 from m⁶A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S5 from m⁶A-Modified SFTA1P Acts as a Tumor Suppressor in Non–Small Cell Lung Cancer by Regulating TGFBR2 and P-TEFb

Key Points

Implication

Abstract

Discussion

Cite This Study

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