Cost-effectiveness analysis reveals cefazolin as the most effective choice for preventing SSI in type III open fractures, highlighting optimal antibiotic selection.
Key Points
CEZ is identified as the most cost-effective regimen for preventing surgical site infections (SSI) in type III open fractures.
Assessment compared six antibiotic regimens based on cost and health utility using data from China's drug pricing policy.
Sensitivity analyses confirmed the reliability of CEZ as a dominant strategy compared to other antibiotics.
Findings support strategic antibiotic selection, optimizing healthcare resources to enhance patient outcomes in surgical care.