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August 7, 2025Reviews in Cardiovascular MedicineOpen Access

Metabolic Alterations Associated With Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: The Modulatory Effects and Improvement Mechanisms of Exercise

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Authors

SCS. ChenGLGuanxiang LiangLClokfai Cheang

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Overview

Review examines how exercise improves metabolic pathways in right ventricular dysfunction associated with pulmonary arterial hypertension, suggesting potential rehabilitation strategies.

Key Points

  • Right ventricular dysfunction significantly impacts exercise capacity and survival in pulmonary arterial hypertension.
  • Mitochondria play a crucial role in energy production and metabolic regulation in the right ventricle.
  • Exercise is identified as a beneficial therapy, potentially enhancing metabolic pathways and right heart function.
  • Understanding these metabolic alterations is vital for developing effective rehabilitation strategies in PAH patients.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d1a69https://doi.org/10.31083/rcm37460
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension2013 · 179 citations
  2. 2Fatty Acid Metabolism in Pulmonary Arterial Hypertension: Role in Right Ventricular Dysfunction and Hypertrophy2015 · 113 citations
  3. 3Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension2022 · 40 citations
  4. 4Cardiometabolic reprogramming drives right ventricular dysfunction in pulmonary arterial hypertension: Novel mechanisms and therapeutic implications2026
  5. 5Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling2016 · 15 citations