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August 8, 2025

Molecular docking and SARs guiding the gradual development of thiazole-2-yl amide derivatives containing biphenyl groups as promising antifungal scaffolds.

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Authors

XCXiang ChengYZYong ZhangFWFanglei Wang

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Overview

Molecular docking and SARs revealed compound G41 as a potent antifungal in targeting B. cinerea, indicating its potential for crop protection.

Key Points

  • Compound G41 demonstrated strong antifungal activity against multiple pathogens, outperforming traditional fungicides.
  • The half maximal effective concentration (EC50) values showed G41 was more effective than boscalid and thifluzamide in inhibiting fungal growth.
  • Molecular docking and structure-activity relationships guided the development of 42 new thiazole derivatives with biphenyl scaffolds.
  • G41's mechanism includes targeting succinate dehydrogenase, leading to significant damage to fungal cells and indicating its potential as a novel fungicide.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/689dfe90d61984b91e13be0dhttps://doi.org/10.1002/ps.70108
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