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August 8, 2025

Polysaccharides Mitigate Alzheimer's Disease Progression by Dynamic Regulation of Gut Microbiota Composition and Metabolites.

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Authors

YGYuan GaoCZChunsheng ZhangLYLiang Yan

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Overview

Experimental treatment reveals cognitive improvement in Alzheimer's disease models, suggesting gut microbiota is crucial for therapeutic effects of polysaccharides.

Key Points

  • CDPS administration significantly reduces cognitive impairment in APP/PS1 Tg mice, highlighting its potential against Alzheimer's disease.
  • Analysis shows that CDPS modulates gut microbiota, specifically improving the Firmicutes/Bacteroidetes ratio, linked to cognitive benefits.
  • Key metabolites D-Proline and Histidine are regulated by CDPS, showing protection against neuronal damage and oxidative stress.
  • Maintaining gut microbiota and immune integrity is essential for maximizing the cognitive benefits of polysaccharides in Alzheimer's models.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13be7fhttps://doi.org/10.1142/s0192415x25500661
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