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September 10, 2025Frontiers in PharmacologyOpen Access

Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omics and experimental validation

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Authors

RLRui LiWSWei SongYNYi Nan

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Overview

Experimental validation shows GCT enhances cognitive function in APP/PS1 mice, suggesting gut microbiota and fatty acid metabolism are involved.

Key Points

  • Cistanche tubulosa glycosides significantly improved spatial memory in APP/PS1 mice, indicating potential cognitive benefits.
  • Glycoside treatment notably reduced Aβ levels and proinflammatory factors, highlighting its neuroprotective effects.
  • Multi-omics results revealed GCT reshapes gut microbiota, promoting beneficial Akkermansia and neuroprotective fatty acids.
  • In vitro analysis confirmed GCT enhances the growth of Akkermansia muciniphila, a probiotic involved in reducing cognitive decline.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1c63e54b1d3bfb60f25c9https://doi.org/10.3389/fphar.2025.1662336
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cistanche tubulosa (Schrenk) Wight Extract Ameliorates Learning and Spatial Memory Abilities in High-Altitude Hypobaric Hypoxia Rats2026
  2. 2A randomized, double‐blind, placebo‐controlled study of <i>Cistanche tubulosa</i> and <i>Ginkgo biloba</i> extracts for the improvement of cognitive function in middle‐aged and elderly people2024 · 6 citations
  3. 3 Polysaccharides Mitigate Alzheimer's Disease Progression by Dynamic Regulation of Gut Microbiota Composition and Metabolites.2025 · 5 citations
  4. 4Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota2025
  5. 5KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites2025 · 5 citations