August 9, 2025

Positive Predictive Value of Tissue Transglutaminase IgA for Celiac Disease.

View Full Paper

Ask AI

Bookmark

Authors

DCDenis ChangBoston Children's Hospital MWMadison WongBoston Children's Hospital MCMaría C. CárdenasBoston Children's Hospital

Discussion

Member takes

Implication

Multicenter retrospective study measures positive predictive value of tTG IgA in diagnosing celiac disease in children, suggesting variability in assay accuracy.

Key Points

The positive predictive value of elevated tTG IgA for celiac disease diagnosis was found to be 82.6% across 4019 children.
Out of children with tTG IgA greater than or equal to 10 times the upper limit of normal, 94.9% were biopsy-confirmed cases of celiac disease.
Diagnostic accuracy of tTG IgA assays varied widely, with a PPV range from 71.5% to 88.8% for differing assays in North America.
Confirming celiac disease diagnosis requires specialist evaluation, especially in children with type 1 diabetes who showed lower PPV.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13bf9f https://doi.org/10.1542/peds.2025-070897

View Full Paper

Ask AI

Bookmark

Implication

Multicenter retrospective study measures positive predictive value of tTG IgA in diagnosing celiac disease in children, suggesting variability in assay accuracy.

Positive Predictive Value of Tissue Transglutaminase IgA for Celiac Disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

Positive Predictive Value of Tissue Transglutaminase IgA for Celiac Disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider