What question did this study set out to answer?

This study aims to evaluate celiac disease screening tests and determine optimal serological thresholds in children with type 1 diabetes mellitus.

Challenge of diagnosing celiac disease in pediatric type 1 diabetes mellitus: lessons from long-term serological surveillance

View Full Paper

Ask AI

Bookmark

This study aims to evaluate celiac disease screening tests and determine optimal serological thresholds in children with type 1 diabetes mellitus.
12-year retrospective single-center cohort study in Türkiye with 282 newly diagnosed T1DM children.
Longitudinal screening for celiac disease in 206 patients; analysis based on receiver operating characteristic (ROC) for tTG-IgA levels.
Biopsy confirmation of celiac disease in identified cases.
tTG-IgA positivity in 24 patients (11.6%); 4.8% of the cohort had biopsy-confirmed celiac disease.
ROC analysis identified optimal tTG-IgA threshold of ≥7.3×ULN with sensitivity of 70%, specificity of 100%.
8.3% of biopsy-confirmed celiac cases had tTG-IgA levels <3×ULN, indicating potential for lower thresholds in diagnosis.

No takes yet. Share an insight, caveat, or question.

Retrospective cohort study assesses celiac disease screening tests in children with type 1 diabetes, suggesting improved diagnostic strategies.

Teke et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Retrospective cohort study assesses celiac disease screening tests in children with type 1 diabetes, suggesting improved diagnostic strategies.