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August 14, 2025

Roxadustat enhances inflammation and metabolic reprogramming in human leukocytes by affecting oxygen sensing.

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Authors

AWAnna WrobelnTSTina SchönbergerYSYves Schild

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Overview

Roxadustat enhances inflammatory responses and metabolic shifts in human leukocytes, indicating its role in immune modulation.

Key Points

  • Roxadustat activates the HIF pathway, enhancing inflammation and metabolic reprogramming in human leukocytes.
  • Single-cell RNA sequencing showed significant shifts in leukocyte subpopulations after roxadustat treatment.
  • The study evaluated effects on leukocyte viability, HIF activation, and metabolic changes using various assays.
  • Findings suggest roxadustat could modulate immune responses and have implications for chronic kidney disease treatment.

Cite This Study

Wrobeln et al. (2025) studied this question.

synapsesocial.com/papers/689fc6852abb084d53ed2422https://doi.org/10.1093/jimmun/vkaf167
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