Effectiveness and safety of subantimicrobial dose doxycycline compared to standard dose doxycycline in the treatment of patients with acne: systematic review and meta‐analysis

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Discussion

Systematic review reveals similar efficacy of subantimicrobial doxycycline, suggesting fewer adverse events in acne treatment.

Subantimicrobial dose doxycycline shows similar effectiveness to standard dose for treating acne lesions, and may have fewer side effects.
No significant differences in inflammatory lesion reduction observed at 4, 8, or 12 weeks in the two treatment groups, confirming comparable efficacy.
Analysis of two randomized clinical trials included data from 762 patients, demonstrating consistency in outcomes between dosing strategies.
Results call for further research to validate findings on safety and effectiveness in larger populations and over extended timeframes.

Quintero et al. (2025) studied this question.

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Authors

Systematic review reveals similar efficacy of subantimicrobial doxycycline, suggesting fewer adverse events in acne treatment.

Subantimicrobial dose doxycycline shows similar effectiveness to standard dose for treating acne lesions, and may have fewer side effects.
No significant differences in inflammatory lesion reduction observed at 4, 8, or 12 weeks in the two treatment groups, confirming comparable efficacy.
Analysis of two randomized clinical trials included data from 762 patients, demonstrating consistency in outcomes between dosing strategies.
Results call for further research to validate findings on safety and effectiveness in larger populations and over extended timeframes.

Quintero et al. (2025) studied this question.

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