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March 19, 2026Saudi Pharmaceutical Journal1 citationsOpen Access

Oral Doxycycline Efficacy and Safety for Acne Vulgaris: Meta-Analysis Insights

Efficacy and safety of oral doxycycline for acne vulgaris treatment: A systematic review and meta-analysis

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Authors

AAAhmad AssiriHHHussam Tariq HakamiADAbdulrahman Daghreeri

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Overview

Systematic review compares efficacy and safety of doxycycline with alternatives in acne vulgaris, suggesting important implications for treatment choices.

Key Points

  • The study aims to compare the efficacy and safety of oral doxycycline with other treatments for acne vulgaris.
  • Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) following PRISMA guidelines.
  • Performed literature searches across multiple databases up to March 2024 using specific medical terms.
  • Primary outcomes included treatment success, inflammatory lesion count, and Global Acne Grading System (GAGS) scores.
  • Evaluated risk of bias using the Cochrane ROB-2 tool and conducted meta-analyses with random-effects models.
  • Doxycycline showed similar efficacy to azithromycin for treatment success but lesser in inflammatory lesion reduction.
  • Other treatments like isotretinoin demonstrated greater improvements in GAGS scores.
  • More adverse events, particularly gastrointestinal and dermatological, were reported with doxycycline.

Cite This Study

Assiri et al. (2026) studied this question.

synapsesocial.com/papers/69bb938e496e729e629817cahttps://doi.org/10.1007/s44446-026-00066-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative efficacy and safety of oral azithromycin versus doxycycline in moderate-to-severe Acne vulgaris: a systematic review and meta-analysis2026 · 1 citations
  2. 2Comparisons of Efficacy and Safety of Different Doses of Doxycycline for the Treatment of Moderate‐to‐Severe Acne Vulgaris: A Systematic Review and Network Meta‐Analysis2025
  3. 3Effectiveness and safety of subantimicrobial dose doxycycline compared to standard dose doxycycline in the treatment of patients with acne: systematic review and meta‐analysis2025
  4. 4Unmasking Acne: Azithromycin Edges Out Doxycycline in Randomized Trial at Tertiary Care Centre2024 · 3 citations
  5. 5Evaluation of the effectiveness of the combination of doxycycline and trifarotene for managing acne vulgaris of moderate to severe severity: a study in a tertiary care hospital2024 · 2 citations