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May 7, 2026Journal of Dermatological Treatment1 citationsOpen Access

Comparative Efficacy and Safety of Azithromycin vs Doxycycline in Acne Vulgaris

Comparative efficacy and safety of oral azithromycin versus doxycycline in moderate-to-severe Acne vulgaris: a systematic review and meta-analysis

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Authors

ABAsia BatoolMAMuhammad Sharjeel AbbasMAMakhzan Ali Akbar

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Overview

Systematic review and meta-analysis demonstrates azithromycin's comparable efficacy and better tolerability than doxycycline in acne vulgaris.

Key Points

  • To compare the efficacy and safety of oral azithromycin and doxycycline in moderate to severe acne vulgaris.
  • Systematic review and meta-analysis following PRISMA guidelines.
  • Comprehensive literature search across different databases.
  • Two reviewers screened studies, extracted data, and assessed risk of bias.
  • Azithromycin reduced non-inflammatory lesions more significantly (MD -7.56; 95% CI -14.33 to -0.79).
  • No significant difference in reducing inflammatory lesions (MD 1.08; 95% CI -0.03 to 2.18).
  • Azithromycin showed better tolerability and fewer side effects compared to doxycycline.

Cite This Study

Batool et al. (2026) studied this question.

synapsesocial.com/papers/69fbefef164b5133a91a415dhttps://doi.org/10.1080/09546634.2026.2648406
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