August 12, 2025International Journal of Reproductive BioMedicine (IJRM)Open Access

Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study

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Authors

YSYasaman SohaniKharazmi University MAMahnaz AzarniaKharazmi University HZHadis ZeinaliKharazmi University

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Implication

Experimental study shows estradiol supplementation improves immature oocyte maturation in NMRI mice with premature ovarian failure, suggesting potential fertility therapies.

Key Points

Estradiol supplementation improved oocyte maturation, with a significance of p < 0.0001.
The lowest percentage of immature oocytes was found in control groups, while highest in sham (76.25%).
Experimental analysis indicated that estradiol doses inversely affected immature oocyte maturation rates.
Findings suggest that 1.5 μg/ml estradiol significantly enhances oocyte maturation in premature ovarian failure models.

Cite This Study

Sohani et al. (2025) studied this question.

synapsesocial.com/papers/68a360f20a429f797332994d https://doi.org/10.18502/ijrm.v23i5.19263

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Implication

Experimental study shows estradiol supplementation improves immature oocyte maturation in NMRI mice with premature ovarian failure, suggesting potential fertility therapies.

Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study

Discussion

Member takes

Implication

Key Points

Cite This Study

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