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July 30, 2025Open Access

A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes

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Authors

VMValeria MericoPRPaola RebuzziniMZMario Zanoni

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Overview

Experiment reveals that elevated 2-hydroxyestradiol levels impair meiotic progression and developmental competence of mouse oocytes, indicating potential risks to fertility.

Key Points

  • Exposure to supra-physiological doses of 2-hydroxyestradiol impaired mouse oocyte maturation and development.
  • Doses of 0.50 and 5.00 µM 2-hydroxyestradiol significantly reduced blastocyst formation rates after fertilization.
  • Morphometric analysis revealed defects in first polar body morphology and asymmetric division during meiosis.
  • Findings suggest that altered cytoskeletal dynamics impact oocyte quality and embryonic viability in mice.

Cite This Study

Merico et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cf01ahttps://doi.org/10.20944/preprints202507.2319.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes2025
  2. 2Excessive estrogenic environment during preimplantation disrupts embryo transport and development and differentially alters the transcriptomes of mouse oviduct and uterus2026
  3. 3Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study2025
  4. 4Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: Phthalate-heat interactions in the ovary2026
  5. 5P-501 Superovulation alters telomere length and telomerase expression in mouse oocytes, possibly by changing estradiol and progesterone levels2024