What question did this study set out to answer?

Investigate the molecular and physiological mechanisms underlying estrogenic endocrine-disrupting chemical-induced oviductal embryo retention using preimplantation 17β-estradiol exposure in pregnant mice.

August 20, 2026Reproductive and Developmental MedicineOpen Access

Excessive estrogenic environment during preimplantation disrupts embryo transport and development and differentially alters the transcriptomes of mouse oviduct and uterus

View Full Paper

Ask AI

Bookmark

Authors

SXShuo XiaoRutgers, The State University of New Jersey HDHonglu DiaoHubei University of Medicine TZTong ZhouQingdao University

Discussion

Member takes

Implication

Animal study demonstrates that preimplantation estradiol exposure induces oviductal embryo retention and transcriptomic changes in mice, indicating pathways underlying ectopic pregnancy.

Key Points

Investigate the molecular and physiological mechanisms underlying estrogenic endocrine-disrupting chemical-induced oviductal embryo retention using preimplantation 17β-estradiol exposure in pregnant mice.
Subcutaneously administered daily doses of 0, 0.1, 1, or 10 µg/kg 17β-estradiol to pregnant mice from day 0.5 to day 2.5 post-coitum.
Harvested oviducts, uteri, and embryos on day 3.5 post-coitum for assessment using embryo flushing, histology, microarray transcriptomic profiling, and real-time PCR validation.
Preimplantation 17β-estradiol caused dose-dependent oviductal embryo retention and developmental delay.
Transcriptomic profiling following 10 µg/kg/day treatment (fold change > 1.5, q-value < 5%) identified 57 differentially expressed genes (33 upregulated, 24 downregulated) in the oviduct versus 2,119 (1,115 upregulated, 1,004 downregulated) in the uterus.
Gene Ontology analysis revealed that 17β-estradiol upregulated immune responses across both tissues, but specifically downregulated oviductal ion transport, metabolism, nutrient transport, and muscle-related functions.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5978a91293e6a1cd090 https://doi.org/10.1097/rd9.0000000000000181

View Full Paper

Ask AI

Bookmark

August 20, 2026Reproductive and Developmental MedicineOpen Access

Excessive estrogenic environment during preimplantation disrupts embryo transport and development and differentially alters the transcriptomes of mouse oviduct and uterus

View Full Paper

Ask AI

Bookmark

Authors

SXShuo XiaoRutgers, The State University of New Jersey HDHonglu DiaoHubei University of Medicine TZTong ZhouQingdao University

Discussion

Member takes

Implication

Animal study demonstrates that preimplantation estradiol exposure induces oviductal embryo retention and transcriptomic changes in mice, indicating pathways underlying ectopic pregnancy.

Key Points

Investigate the molecular and physiological mechanisms underlying estrogenic endocrine-disrupting chemical-induced oviductal embryo retention using preimplantation 17β-estradiol exposure in pregnant mice.
Subcutaneously administered daily doses of 0, 0.1, 1, or 10 µg/kg 17β-estradiol to pregnant mice from day 0.5 to day 2.5 post-coitum.
Harvested oviducts, uteri, and embryos on day 3.5 post-coitum for assessment using embryo flushing, histology, microarray transcriptomic profiling, and real-time PCR validation.
Preimplantation 17β-estradiol caused dose-dependent oviductal embryo retention and developmental delay.
Transcriptomic profiling following 10 µg/kg/day treatment (fold change > 1.5, q-value < 5%) identified 57 differentially expressed genes (33 upregulated, 24 downregulated) in the oviduct versus 2,119 (1,115 upregulated, 1,004 downregulated) in the uterus.
Gene Ontology analysis revealed that 17β-estradiol upregulated immune responses across both tissues, but specifically downregulated oviductal ion transport, metabolism, nutrient transport, and muscle-related functions.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5978a91293e6a1cd090 https://doi.org/10.1097/rd9.0000000000000181

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark