Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 17, 2025Journal of Developmental BiologyOpen Access

A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes

View Full Paper
Ask AI
Bookmark
Share

Authors

VMValeria MericoPRPaola RebuzziniMZMario Zanoni

Discussion

Loading...

Member takes

Overview

This study demonstrates that supra-physiological doses of 2-hydroxyestradiol impair oocyte maturation and embryo development, highlighting risks for ovarian function.

Key Points

  • Supra-physiological doses of 2-hydroxyestradiol impair meiotic progression and significantly reduce embryo development.
  • At concentrations of 0.50 and 5.00 µM, oocyte maturation is notably compromised, leading to defective meiotic structures.
  • The study examines the impact of varying doses on oocyte quality, revealing alterations in cytoskeletal dynamics and cell architecture.
  • Findings suggest high 2-hydroxyestradiol levels may disrupt key processes critical for successful meiosis and embryogenesis.

Cite This Study

Merico et al. (2025) studied this question.

synapsesocial.com/papers/68f199b7de32064e504dc6ebhttps://doi.org/10.3390/jdb13040037
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes2025
  2. 2Excessive estrogenic environment during preimplantation disrupts embryo transport and development and differentially alters the transcriptomes of mouse oviduct and uterus2026
  3. 3Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study2025
  4. 4Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: Phthalate-heat interactions in the ovary2026
  5. 5P-501 Superovulation alters telomere length and telomerase expression in mouse oocytes, possibly by changing estradiol and progesterone levels2024