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August 16, 2025Endodontics TodayOpen Access

Histopathological patterns of periapical lesions in root canal treated teeth: A systematic review

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Authors

BGB. D. Gupta

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Overview

Systematic review summarizes histopathological features and diagnostic challenges of periapical lesions.

Key Points

  • Histopathological examination reveals periapical granulomas as the most prevalent lesions, found in 50-84.2%.
  • Twelve studies with 1,847 specimens show poor clinical-histopathological concordance, ranging from 51.4% to 55.8%.
  • Systematic review conducted following PRISMA 2020 guidelines, assessing quality with Newcastle-Ottawa Scale and QUADAS-2 tools.
  • Significant discrepancies between clinical and histopathological diagnoses highlight the importance of biopsy for accurate diagnosis.

Cite This Study

B. D. Gupta (2025) studied this question.

synapsesocial.com/papers/68a3669b0a429f797332c45fhttps://doi.org/10.36377/et-0117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Histopathological Spectrum of Periapical Lesions in Root Canal-Treated and Non-root Canal-Treated Teeth2026
  2. 2Periapical Lesions: Diagnosis, Pathophysiology, and Management2026
  3. 3Radiographic and Histological Correlation of Large Periapical Lesions: A Retrospective Analysis2026
  4. 4Comparative Healing Outcomes of Periapical Lesions with Different Histopathological Features Following Endodontic versus Surgical Management2026
  5. 5Influence of Imaging Modality on the Detection of Periapical Lesions in Root‐Filled Teeth: A Systematic Review and Meta‐Analysis2026