What does this research mean for the field?

Periapical lesions in root canal-treated teeth are more likely to present as radicular cysts with chronic inflammation, whereas those in non-root canal-treated teeth more frequently present as granulomas with acute inflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the histopathological diagnoses and predominant inflammatory patterns of periapical lesions between root canal-treated and non-root canal-treated teeth.

September 8, 2026CureusOpen Access

Comparative Histopathological Spectrum of Periapical Lesions in Root Canal-Treated and Non-root Canal-Treated Teeth

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Authors

SKSachin Kandalkar SGSadhvi Gupta CMChidipothu Sri Madhavi

Discussion

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Overview

Comparative cross-sectional study reveals higher rates of radicular cysts in root canal-treated teeth, indicating distinct pathological mechanisms underlying persistent periapical disease.

Key Points

To compare the histopathological diagnoses and predominant inflammatory patterns of periapical lesions between root canal-treated and non-root canal-treated teeth.
Conducted a comparative cross-sectional study of 120 periapical tissue specimens (60 from root canal-treated teeth and 60 from non-root canal-treated teeth) collected via apical surgery or extraction.
Stained specimens with hematoxylin and eosin for independent evaluation by two blinded oral and maxillofacial pathologists (interobserver agreement: κ=0.874 for diagnosis, κ=0.805 for inflammation).
Categorized lesions into periapical granuloma, radicular cyst, periapical abscess, or indeterminate, and classified inflammation patterns as chronic, acute, or mixed using chi-squared and Fisher's exact tests.
Radicular cysts were significantly more prevalent in root canal-treated teeth than in non-treated teeth (46.7% vs. 23.3%; OR=2.88; 95% CI: 1.31–6.30; p=0.012), whereas periapical granulomas were significantly less frequent (33.3% vs. 53.3%; OR=0.44; 95% CI: 0.21–0.92; p=0.042).
Periapical abscess rates did not differ significantly between root canal-treated and non-treated teeth (13.3% vs. 16.7%; OR=0.77; 95% CI: 0.28–2.11; p=0.799).
Predominant chronic inflammation was significantly more common in root canal-treated specimens (56.7% vs. 36.7%), whereas acute inflammation predominated in non-treated specimens (13.3% vs. 33.3%; χ²=7.71; p=0.021).

Cite This Study

Kandalkar et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7d558e84d0ff5b46df7 https://doi.org/10.7759/cureus.115873

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September 8, 2026CureusOpen Access

Comparative Histopathological Spectrum of Periapical Lesions in Root Canal-Treated and Non-root Canal-Treated Teeth

View Full Paper

Ask AI

Bookmark

Authors

SKSachin Kandalkar SGSadhvi Gupta CMChidipothu Sri Madhavi

Discussion

Member takes

Overview

Comparative cross-sectional study reveals higher rates of radicular cysts in root canal-treated teeth, indicating distinct pathological mechanisms underlying persistent periapical disease.

Key Points

To compare the histopathological diagnoses and predominant inflammatory patterns of periapical lesions between root canal-treated and non-root canal-treated teeth.
Conducted a comparative cross-sectional study of 120 periapical tissue specimens (60 from root canal-treated teeth and 60 from non-root canal-treated teeth) collected via apical surgery or extraction.
Stained specimens with hematoxylin and eosin for independent evaluation by two blinded oral and maxillofacial pathologists (interobserver agreement: κ=0.874 for diagnosis, κ=0.805 for inflammation).
Categorized lesions into periapical granuloma, radicular cyst, periapical abscess, or indeterminate, and classified inflammation patterns as chronic, acute, or mixed using chi-squared and Fisher's exact tests.
Radicular cysts were significantly more prevalent in root canal-treated teeth than in non-treated teeth (46.7% vs. 23.3%; OR=2.88; 95% CI: 1.31–6.30; p=0.012), whereas periapical granulomas were significantly less frequent (33.3% vs. 53.3%; OR=0.44; 95% CI: 0.21–0.92; p=0.042).
Periapical abscess rates did not differ significantly between root canal-treated and non-treated teeth (13.3% vs. 16.7%; OR=0.77; 95% CI: 0.28–2.11; p=0.799).
Predominant chronic inflammation was significantly more common in root canal-treated specimens (56.7% vs. 36.7%), whereas acute inflammation predominated in non-treated specimens (13.3% vs. 33.3%; χ²=7.71; p=0.021).

Cite This Study

Kandalkar et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7d558e84d0ff5b46df7 https://doi.org/10.7759/cureus.115873

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