August 16, 2025

Limited efficacy of cold and heat therapy as adjunctive treatments for local, systemic, and functional outcomes of Bothrops atrox snakebite envenomation: A randomized clinical trial.

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Discussion

Randomized trial found no significant improvement in outcomes for bothroups with cold or heat therapy, showing CTG reduced pain.

No significant differences in creatine kinase reduction observed among all groups at 48 hours, indicating limited efficacy of adjunctive therapies.
Cold Therapy Group showed a notable decrease in pain within 24 hours, suggesting potential benefits of cold interventions in snakebite treatment.
The randomized clinical trial included 94 patients, balancing groups among cold therapy, heat therapy, and control for robust comparisons.
Adjunctive heat therapy proved ineffective, emphasizing the need for careful consideration of additional treatments in snakebite management.

Almeida et al. (2025) studied this question.

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August 16, 2025

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Authors

Randomized trial found no significant improvement in outcomes for bothroups with cold or heat therapy, showing CTG reduced pain.

No significant differences in creatine kinase reduction observed among all groups at 48 hours, indicating limited efficacy of adjunctive therapies.
Cold Therapy Group showed a notable decrease in pain within 24 hours, suggesting potential benefits of cold interventions in snakebite treatment.
The randomized clinical trial included 94 patients, balancing groups among cold therapy, heat therapy, and control for robust comparisons.
Adjunctive heat therapy proved ineffective, emphasizing the need for careful consideration of additional treatments in snakebite management.

Almeida et al. (2025) studied this question.

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