August 16, 2025

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism.

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The cryo-EM structure shows a novel allosteric mechanism for activating factor X in hemostasis.
A resolution of 3.7 Å was achieved while modeling a complex of tissue factor, factor VIIa, and a factor X mimetic.
Membrane-bound assemblies of tissue factor and factor VIIa exhibit unique interactions, enabling activation of factor X.
This work highlights the membrane dependence of factor activation, suggesting new avenues for understanding thrombosis.

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Cryo-EM structure uncovers a novel allosteric mechanism in tissue factor/factor VIIa activation of factor X, indicating implications for hemostasis.

Sedzro et al. (2025) studied this question.

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Cryo-EM structure uncovers a novel allosteric mechanism in tissue factor/factor VIIa activation of factor X, indicating implications for hemostasis.