Population
Preclinical model studying mammalian Tissue Factor (TF) activation
Comparison
Ablation of the allosteric disulfide bond by… vs Wild-type or untreated Tissue Factor
Design
Preclinical
Authors
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Animal data on TF disulfide should not change practice; leaves open Cys186-Cys209 targeting for thrombosis research.
The activation of Tissue Factor from its cryptic form involves the formation of the Cys186-Cys209 allosteric disulfide bond, which facilitates the binding of coagulation factors IX and X.
Chen et al. (2006) studied this question.
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