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This is a Human Clinical Trial study.

Electromechanical Resynchronization with High Energy Septal Pacing

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Electromechanical resynchronization improves cardiac function in patients with severe conduction disorders, indicating benefits of septal pacing.

High energy septal pacing improves QRS duration and ejection fraction in patients with severe conduction disorders, while other pacing sites do not.
Patients with severe left bundle branch block showed a significant 14% increase in left ventricular dP/dtmax with high energy septal pacing.
Assessment of 30 patients included evaluations of QRS duration, isovolumetric contraction time, and ejection fraction during pacing.
High energy septal pacing was ineffective for patients without conduction disorders, where traditional pacing methods improved outcomes.

Barja et al. (2025) studied this question.

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Electromechanical resynchronization improves cardiac function in patients with severe conduction disorders, indicating benefits of septal pacing.