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August 17, 2025International Journal of Molecular SciencesOpen Access

Syringic Acid Alleviates Doxorubicin-Induced Hepatotoxicity Through PI3K/Akt-Mediated Nrf-2/HO-1 Signaling Pathways in Male Rats

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Authors

MAMaha Abdullah AlwailiPrincess Nourah bint Abdulrahman UniversityTEThamir M. EidKing Abdulaziz UniversityAAAmal S. Abu-AlmakaremAl Baha University

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Implication

Experimental analysis demonstrates syringic acid's protective effects against hepatotoxicity in rats, suggesting therapeutic potential for doxorubicin treatment.

Key Points

  • Syringic acid significantly reduced doxorubicin-induced hepatotoxicity in male rats, and improved liver function markers were noted after treatment.
  • Biochemical analyses showed a substantial decrease in oxidative stress and inflammation in rats treated with syringic acid.
  • Molecular docking studies were conducted to understand the interaction of syringic acid with relevant pathways, including PI3K/Akt and Nrf-2/HO-1 signaling.
  • These findings underscore the potential of syringic acid as a hepatoprotective agent in doxorubicin therapy, pointing to the need for further clinical studies.

Cite This Study

Alwaili et al. (2025) studied this question.

synapsesocial.com/papers/68a36a560a429f797332f25bhttps://doi.org/10.3390/ijms26167779
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