Gut Microbiome and Adult Obesity: Exploring the Weight Loss Potential of Probiotics, Prebiotics, and Synbiotics as Strategies with Potential Implications for Cancer Prevention

Probiotics, prebiotics, and synbiotics are examples of Gut Microbiome (GM)therapies that have been investigated as possible weight-management techniques in light of the growing worldwide health concern around obesity. Through a meta-analysis of remaining research, this research aims to assess the possessions of various therapies on metabolic parameters, weight reduction, with the makeup of the GM. Weight loss, variations in the microbiome, and possible negative consequences were evaluated by analyzing data from several research. The findings revealed a moderate but irregular decrease in weight, with decreases noted in (-1.8 kg) and (-2.3%). Although there have been reports of notable increases in helpful bacteria, such as Lactobacillus and Bifidobacterium, it is unclear whether these bacteria directly contribute to long-term weight loss. The requirement for more thorough clinical trials was highlighted by the detection of possible publication bias, even though most therapies were well-tolerated. Overall, the results point to the possibility that GM modification could promote metabolic health.