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This review explores how gut microbiota influences weight management and suggests therapeutic strategies for obesity, indicating the need for personalized approaches.
The gut microbiota is increasingly recognized as a key regulator of host metabolism, influencing energy balance, fat storage, and weight management. Dysbiosis, or imbalance in gut microbial composition, has been associated with obesity and metabolic disorders. Microbial metabolites, such as short-chain fatty acids, interact with host receptors and the gut-brain axis to modulate appetite, satiety, and insulin sensitivity. Interventions including probiotics, prebiotics, and dietary modifications show potential for restoring microbial balance and promoting weight loss, though individual responses vary. Environmental factors, lifestyle, and diet profoundly shape gut microbiota composition, emphasizing the importance of personalized approaches. This review highlights the mechanisms linking gut microbiota to weight regulation and discusses therapeutic strategies for obesity management.
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Andressa dos Reis Gonçalves Mariani (2025) studied this question.
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