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August 17, 2025Archive of oncologyOpen Access

Comparation of animal models of acute toxicity of doxorubicin

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Authors

MBMilana BosanacUniversity of Novi SadBABojana Andrejić-VišnjićUniversity of Novi SadGSGolub SamardžijaInstitute for Cardiovascular Diseases of Vojvodina

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Implication

This research demonstrates acute cardiotoxicity and oxidative stress in animal models, indicating dose impact.

Key Points

  • Both doses of doxorubicin caused significant cardiac damage and oxidative stress in Wistar rats, indicating clear cardiotoxicity.
  • The higher dose (20 mg/kg) resulted in worse conditions and higher mortality rates compared to the lower dose (15 mg/kg).
  • Observational analysis involved measuring lipid peroxidation, antioxidant enzyme activity, and myocardial tissue damage scores.
  • These findings suggest a need for cautious use of higher doses in future studies of acute doxorubicin toxicity and oxidative stress.

Cite This Study

Bosanac et al. (2025) studied this question.

synapsesocial.com/papers/68a36dd90a429f7973330f6fhttps://doi.org/10.2298/aoo250224008b
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