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August 15, 2025Pharmacological ResearchOpen Access

Ultrasound-activated poly(butyl cyanoacrylate) microbubbles enhance the therapeutic effect of Doxil

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Authors

JBJulia BlöckLILea ImschweilerRMRahaf Mihyar

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Overview

Observational analysis reveals enhanced tumor response with PBCA microbubble-assisted drug delivery, suggesting improved therapeutic strategies.

Key Points

  • Enhanced tumor responses lead to improved inhibition of growth and reduced cancer cell proliferation, indicating the effectiveness of PBCA microbubbles.
  • Key evidence shows that combining PBCA microbubbles with low-dose Doxil results in notable apoptosis and cellular uptake changes.
  • This approach utilized a method combining microbubble technology with ultrasound to enhance drug penetration and efficacy in treatment.
  • These findings highlight the potential implications for clinical applications, calling for further exploration in translational research.

Cite This Study

Blöck et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3d64https://doi.org/10.1016/j.phrs.2025.107916
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro and in vivo sonoporation using hard-shelled poly (n-butyl cyanoacrylate) microbubbles to improve drug delivery to breast cancer2025
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  4. 4Enhanced Antitumor Efficacy and Reduced Cardiotoxicity of Ultrasound-Mediated Doxorubicin Delivery by Microbubble-Liposome Complexes2025 · 8 citations
  5. 5Microbubbles bound to drug-eluting beads enable ultrasound imaging and enhanced delivery of therapeutics2024 · 4 citations