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June 7, 2026BiomoleculesOpen Access

PLLA@PDA-DOX Nanobubbles for Ultrasound Imaging Combined Chemo-Photothermal Therapy

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Authors

JZJie ZhangXLXinyi LiHZH Zhang

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Overview

Randomized trial demonstrates enhanced antitumor efficacy in cancer treatment, suggesting improved therapies for patients.

Key Points

  • This study aims to develop PLLA@PDA-DOX nanobubbles for combined ultrasound imaging and photothermal chemotherapy.
  • Fabricated PLLA@PDA-DOX nanobubbles with a mean diameter of 489.30 ± 6.96 nm and a PDI of 0.226.
  • Evaluated the toxicity in mice, assessing the maximum tolerated dose compared to clinical equivalents.
  • Tested therapeutic efficacy using HCCLM3 cells under near-infrared laser irradiation.
  • Inhibition rate of HCCLM3 cells increased from 50.1% to 64.45% under NIR irradiation.
  • Survival rate of LX-2 cells increased from 18.9 ± 1.56% to 68.8 ± 3.08% in the composite nanobubble group.
  • PLLA@PDA-DOX nanobubbles showed excellent biocompatibility and robust ultrasound imaging performance.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a250c027def13d035e1bfb3https://doi.org/10.3390/biom16060834
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