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November 28, 2025Langmuir

Water-Soluble DOX·HCl Delivery Nanoplatform for Efficient Photothermal Therapy with Chemotherapy: Polydopamine and Mesoporous Silica-Coated Gold Nanorods

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Authors

FZFusheng ZhangSPShiyuan PengXHXiaolan Huang

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Overview

Analysis reveals enhanced antitumor activity in tumor microenvironment using doxorubicin hydrochloride with near-infrared irradiation, suggesting benefits of combined therapies.

Key Points

  • Cytotoxicity assays demonstrated enhanced antitumor activity from the nanoplatform compared to free doxorubicin hydrochloride.
  • A cumulative release of 66% of doxorubicin hydrochloride was achieved under pH 5.0 conditions, with near-infrared irradiation increasing release by 10%.
  • The study designed a nanostructure with polydopamine-modified gold nanorods for controlled drug release and effective photothermal therapy.
  • The results highlight the potential of chemotherapy and photothermal therapy synergy within the tumor microenvironment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a6aehttps://doi.org/10.1021/acs.langmuir.5c04649
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