LipiDecipher reveals novel mechanisms in myocardial infarction, highlighting insights for lipidomics research.
Abstract LipiDecipher is a structure-oriented framework designed to overcome the functional interpretation bottleneck in lipidomics. By integrating lipid-protein-pathway mapping with a unique lipid deconstruction algorithm, it connects molecular structure to biological function. Analyzing a myocardial infarction cohort, LipiDecipher revealed novel mechanisms, including a progressive depletion of phosphatidylinositol-associated fatty acids in recurrent patients, which points to deteriorating membrane repair capacity. This powerful paradigm enables the discovery of novel biological insights and robust biomarkers, significantly advancing clinical lipidomics research.
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Huang et al. (2025) studied this question.
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