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August 19, 2025Journal of VirologyOpen Access

Influence of the pre-membrane and envelope proteins on structure, pathogenicity, and tropism of tick-borne encephalitis virus

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Authors

EREbba RosendalKBKyrylo BisikaloSWStefanie M. A. Willekens

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Overview

Research reveals surface proteins affect tropism in the brain for tick-borne encephalitis virus, suggesting other factors are also crucial.

Key Points

  • The chimeric virus maintains low pathogenicity while showing structural similarities to tick-borne encephalitis virus, highlighting its relevance.
  • Both the chimeric virus and Langat virus primarily infect the cerebral cortex, with TBEV showing a distinct preference for Purkinje cells.
  • This analysis utilizes advanced imaging techniques to explore virus distribution across brain regions in mouse models.
  • Findings indicate that non-structural proteins or other viral components significantly affect TBEV tropism in the brain.

Cite This Study

Rosendal et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead408ahttps://doi.org/10.1128/jvi.00870-25
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