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September 10, 2025Emerging Microbes & InfectionsOpen Access

Three-dimensional mapping of tick-borne encephalitis virus distribution in the mouse brain using a newly engineered TurboGFP reporter virus

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Authors

MBMichaela BeránkováCzech Academy of SciencesSLStefania LeoniIstituto Giannina GasliniJHJiří HoloubekInstitute of Parasitology of the Slovak Academy of Sciences

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Overview

Study utilizes TurboGFP reporter virus to track tick-borne encephalitis virus distribution in mouse brain, highlighting viral tropism.

Key Points

  • High-resolution mapping revealed distinct patterns of tick-borne encephalitis virus distribution in the mouse brain.
  • tGFP-TBEV enabled precise tracking of viral replication and supported screening for potential antiviral compounds.
  • Use of light-sheet fluorescence microscopy allowed for three-dimensional visualization of TBEV infection in the central nervous system.
  • This approach enhances understanding of viral tropism and pathogenesis in tick-borne encephalitis, paving the way for new insights.

Cite This Study

Beránková et al. (2025) studied this question.

synapsesocial.com/papers/68c19f7f54b1d3bfb60dabbahttps://doi.org/10.1080/22221751.2025.2542246
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