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August 19, 2025Open Access

Supplementary Figure S2 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Jun Li Zoe Welham Benita Tse Chahaya Gauci Shila Ghazanfar Pratibha Panwar Alexander Engel Mark P. Molloy

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Key Points

High-risk oncogenic drivers were identified in low-grade bowel polyps, suggesting a distinct subgroup.
Concurrent oncogenic alterations appear independent of polyp size, indicating genetic complexities in tumorigenesis.
Analysis used MSI scores based on the MSIsensor-pro method to classify sample cohorts effectively.
Findings point to the need for tailored surveillance strategies based on mutational profiles in bowel polyps.

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Implication

Mutational analysis reveals concurrent high-risk oncogenic drivers in bowel polyps, suggesting a new subgroup with specific MSI scores.

Abstract

MSI scores in the sample cohort, estimated by MSIsensor-pro.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af4953ad7bf08b1ead5271 https://doi.org/10.1158/2767-9764.29939590

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
2Supplementary Figure S4 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
3Supplementary Figure S9 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
4Supplementary Figure S7 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
5Supplementary Figure S3 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025

Table 1 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
Supplementary Figure S5 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025