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This is a In Vitro Study study.

Synthesis of Alpha‐Acyloxy‐(1,2,5‐Oxadiazole‐2‐Oxide) Carboxamides via Passerini Multicomponent Reaction. Evaluation of Nitric Oxide‐Releasing and Anti‐Proliferative Properties

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Passerini reaction produced nitric oxide-releasing furoxan carboxamides, suggesting potential antitumor activity.

All synthesized compounds released nitric oxide ranging from 0.8 to 7.4 μM, indicating their effectiveness as NO donors.
Two compounds showed moderate anti-proliferative activity against LNCaP cancer cells with IC50 values of 95.5 and 66.6 μM.
This study utilized multicomponent reactions under microwave heating to achieve moderate to excellent yields of carboxamides.
Furoxan hybrid molecules represent a promising class of compounds for further evaluation in cancer therapy.

Anjos et al. (2025) studied this question.

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