Key result
4-Phenyl-3-furoxancarbonitrile donates nitric oxide to induce vasodilation and inhibit platelet aggregation in rats.
Population
Preclinical models (rat lung soluble guanylate cyclase, rat thoracic aorta strips, platelets)
Design
Preclinical
Authors
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Should not change practice; leaves open translation of furoxan NO donors to human cardiovascular trials.
4-Phenyl-3-furoxancarbonitrile is a promising nitric oxide donor with potent vasodilatory and antiplatelet effects in preclinical models.
Medana et al. (1994) studied this question. 4-Phenyl-3-furoxancarbonitrile was evaluated on Guanylate cyclase activation, vasodilatory activity, and platelet aggregation inhibition. 4-Phenyl-3-furoxancarbonitrile acts as a nitric oxide donor, efficiently activating soluble guanylate cyclase, inducing vasodilation in rat aorta, and inhibiting platelet aggregation.
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