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August 22, 2025TransplantationOpen Access

Does NRF2 Play a Double-edged Role in Acute GVHD Pathogenesis?

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Authors

KWKangyu WangLYLi Yang

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Overview

Observational analysis identifies NRF2 as a promoter of T-cell activation in acute graft-versus-host disease, suggesting new therapeutic avenues.

Key Points

  • NRF2 plays a complex role in aGVHD, acting as a promoter of T-cell hyperactivation rather than simply as a protective factor.
  • Patients with aGVHD show significantly elevated NRF2 levels in CD4+ T cells, which correlate with disease severity.
  • Pharmacologic inhibition of NRF2 reduces key T-cell activation markers, indicating its pivotal role in cytokine signaling.
  • Targeting NRF2 could become a feasible therapeutic strategy for managing T-cell activation in aGVHD, warranting further investigation.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af5228ad7bf08b1eada3cbhttps://doi.org/10.1097/tp.0000000000005513
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  1. 1Decoding TNF receptor superfamily control of CD4+Foxp3+ Regulatory T cell-mediated tolerance: implications for the treatment of graft‑versus‑host disease2026
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