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August 14, 2025International Journal of Molecular SciencesOpen Access

Benzofuran Derivatives with Antimicrobial and Anti-Inflammatory Activities from Penicillium crustosum SCNU-F0046

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Authors

CCChen ChenHeilongjiang Provincial Environmental Science Research InstituteJKJiabing KangGuiyang Medical UniversityRZRuiqi ZhangTianjin Normal University

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Implication

Investigation reveals benzofuran compounds exhibit antimicrobial and anti-inflammatory effects, suggesting potential therapeutic applications.

Key Points

  • Compound 1 demonstrates moderate antibacterial activity, indicating its potential as an antimicrobial agent.
  • Anti-inflammatory evaluation shows compounds 1 and 4 inhibit nitric oxide release with IC50 values around 17.3 μM and 16.5 μM, respectively.
  • Analysis utilized techniques like mass spectrometry and X-ray crystallography to elucidate structures of the derivatives.
  • Findings highlight the promising therapeutic potential of benzofurans from Penicillium crustosum in combating inflammation and infections.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af5407ad7bf08b1eadacb2https://doi.org/10.3390/ijms26167861
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